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目的探讨研究武陵山区绝经综合征患者戊酸雌二醇片补充治疗依从性影响因素。方法对2013年3月-2015年3月潍坊市妇幼保健院收治的110例绝经综合征患者的病历资料进行回顾性调查分析,所有患者均行戊酸雌二醇片补充治疗,对影响治疗依从性的因素进行回归分析。结果单因素分析发现,影响程度由高到低依次是:经济收入、医源性因素、对戊酸雌二醇片的认知、担心发生不良反应、家庭支持、文化程度、取药条件、心理状态;对以上单因素进行多因素Logistic回归分析,发现家庭支持(OR=3.248)是保护因素,而经济收入低(OR=4.703)、医源性差(OR=4.265)、对戊酸雌二醇片的认知偏差(OR=4.061)、担心发生不良反应(OR=3.896)是独立危险因素。结论对武陵山区绝经综合征采用戊酸雌二醇片补充治疗患者需要改善医源性条件,加强对该药物的认知宣教,鼓励家庭成员对患者进行支持,以提高其依从性。
Objective To investigate the influencing factors of adherence of estradiol valerate tablets in patients with menopausal syndrome in Wuling Mountain. Methods The data of 110 cases of menopausal syndrome admitted to Weifang Maternal and Child Health Hospital from March 2013 to March 2015 were retrospectively analyzed. All the patients were treated with estradiol valerate tablets, Sexual factors for regression analysis. Results According to the univariate analysis, the order of influence was: economic income, iatrogenic factors, cognition of estradiol valerate tablets, fears of adverse reactions, family support, educational level, taking medicine conditions, psychology (OR = 3.248) was the protective factor, while the economic income was low (OR = 4.703), iatrogenic poor (OR = 4.265), estradiol valerate The cognitive bias (OR = 4.061) and the fear of adverse events (OR = 3.896) were independent risk factors. Conclusion In patients with menopause syndrome in Wuling Mountain, estradiol valerate tablets need to be improved to improve iatrogenic conditions, to strengthen awareness of the drug, and to encourage family members to support patients to improve their compliance.