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在酸性条件下,盐酸阿米替林分子中氮原子被质子化后与阴离子AuCl4-形成离子缔合物,该缔合物被二氯甲烷带入鲁米诺的氯化十六烷基三甲基铵反胶束纳米微反应器中,离解出来的AuCl4-立即与鲁米诺产生化学发光。在一定浓度范围内,发光强度与盐酸阿米替林的含量成线性关系,从而间接测定盐酸阿米替林的含量。在优化的实验条件下,线性范围为0.001～15μg/mL,检出限(3δ)为0.03 ng/mL,对浓度为1.0μg/mL的盐酸阿米替林进行11次平行测定,RSD为2.4%。该法已用于片剂和生物体液中盐酸阿米替林的测定。
Under acidic conditions, the nitrogen atom in the amitriptyline hydrochloride molecule is protonated to form an ion association with the anion AuCl4-, and the association product is brought into the luminol chloride cetyltrimethylammonium chloride Ammonium reverse micellar nanoreactor, the dissociated AuCl4- luminol with chemiluminescence immediately. In a certain concentration range, the luminescence intensity and the linear relationship between the content of amitriptyline hydrochloride, indirect determination of amitriptyline hydrochloride content. Under the optimized experimental conditions, the linear range was 0.001 ~ 15μg / mL, the detection limit (3δ) was 0.03 ng / mL, and 11 parallel determinations of amitriptyline hydrochloride at a concentration of 1.0μg / mL showed a RSD of 2.4 %. This method has been used for the determination of amitriptyline hydrochloride in tablets and biological fluids.