论文部分内容阅读
许多研究者已观察到急性酒精中毒(酒精潮红)存在个体和种族的差异。蒙古族个体(50～85%)比高加索族个体(5～10%)更容易发生酒精潮红。乙醇的氧化途径主要是通过乙醇脱氢酶Ⅰ型(乙醇:NAD+氧化还原酶,ADH)和醛脱氢酶(醛:NAD+氧化还原酶,ALDH)进行催化,东方人(90%)肝的ADH活性比高加索人更高,而约50%东方人肝和其它组织内缺乏一种ALDH同工酶活性,即线粒体ALDH 2。由于缺乏ALDH同工酶活性,致使体内蓄积乙醛,故而东方人酒精潮红的频率高。据目前报道所知,所有高加索人均有ALDH2活性,故高加索人酒精潮红不是由
Many researchers have observed individual and ethnic differences in acute alcoholism (alcohol flushing). Mongolian individuals (50-85%) are more likely to experience alcohol flushing than Caucasians (5-10%). The oxidation pathway of ethanol is mainly catalyzed by alcohol dehydrogenase type Ⅰ (ethanol: NAD + oxidoreductase, ADH) and aldehyde dehydrogenase (aldehyde: NAD + oxidoreductase, ALDH) Activity is higher than in Caucasians, while about 50% of oriental human liver and other tissues lack an ALDH isoenzyme activity, mitochondrial ALDH 2. Due to the lack of ALDH isoenzyme activity, resulting in the accumulation of acetaldehyde in the body, so the frequency of alcohol flushing in the East is high. As far as is currently reported, all Caucasians have ALDH2 activity, so Caucasian alcohol flushing is not caused by