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43例结直肠癌患者术中取癌灶粘液及远端正常肠粘液,经ELISA法测定其肿瘤坏死因子(TNF-α)的水平。结果显示,同一结直肠癌患者远离癌灶的正常肠粘液TNF-α水平明显高于癌灶组(P<0.O1),提示癌灶部分肠组织中单核细胞分泌TNF-α活性受到抑制,正常远端肠组织因肿瘤负荷导致TNF-α内源性升高,而晚期TNF-α活性明显低于早期患者,临床随诊也提示这部分病人预后较差。检测肠癌患者肠粘液TNF-α的水平,可作为肠癌疗效评价及病情预后的指标。
Forty-three patients with colorectal cancer underwent intramuscular mucosa and distal normal intestinal mucosa, and the levels of tumor necrosis factor (TNF-α) were measured by ELISA. The results showed that in the same colorectal cancer patients with normal intestinal mucosa away from the foci TNF-α levels were significantly higher than that of the foci group (P <0.O1), suggesting that part of the foci in the gut tissue monocytes secreting TNF-α activity was inhibited In normal distal intestine tissue, TNF-αincreased endogenously due to tumor burden, while late TNF-αactivity was significantly lower than that in early stage. Clinical follow-up also indicated that this part of patients had poor prognosis. Detection of intestinal mucosa TNF-α levels in patients with colorectal cancer can be used as an indicator of efficacy and prognosis of colorectal cancer.