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Sparfloxacin是一种氟喹诺酮类药物,作者用动力法在裸鼠足垫上对其抗麻风活性进行了检测。首次实验用连续给药法,分别以2、5和10mg/kg每日管饲给药一次,每周5—6次。第二次实验用间歇给药法,饲管给药,按l0和20mg/kg每周二次,或30mg/kg每周一次。将5周龄的BLAB/c雌性裸鼠随机分为10只一组.每只裸鼠的双后足垫各接种107条麻风菌,在特定的时间裸鼠足垫计数AFB。连续给药组于接种后60一152天分别按2、5和10mg/k8的剂量给药;2只未治疗的裸鼠在接种后8个月和9个月时,每只足垫盼平均菌量为106。条,11个月时接近lO10条;2mg/kg组的接种后8个月和11个月时,平均菌量分别为3×107条和108条以上;5mg/kg组的平均菌量在接种后9个月内一直低于接种水平,但在lO个月和11个月
Sparfloxacin, a fluoroquinolone drug, has been tested for anti-leprosy activity on the footpad in nude mice using a kinetic method. The first experiment with continuous administration, respectively, 2,5 and 10mg / kg administered once daily gavage, 5-6 times per week. The second experiment with intermittent administration, feeding tube, press l0 and 20mg / kg twice a week, or 30mg / kg once a week. Five-week-old female BALB / c nude mice were randomized into groups of 10. Two nude hindpaws of each nude mouse were inoculated with 107 leprosy bacteria and their nude mice footpad count AFB at specific times. The continuous administration groups were administered at doses of 2, 5 and 10 mg / kg at 60 to 152 days after inoculation, respectively. The average height of each of the two untreated nude mice at 8 and 9 months after inoculation was The amount of bacteria is 106. The number of bacteria in the 2mg / kg group was 3 × 107 and more than 108 at 8 and 11 months after inoculation, respectively. The average amount of bacteria in the 5mg / kg group After 9 months has been below the level of vaccination, but in lO months and 11 months