促红细胞生成素(Erythropoieti Epo)是促进骨髓红系祖细胞生长、增殖、分化和成熟的主要刺激因子,在高原红细胞增多症(HAPC)发病机理中起关键性作用。本文采用Epo多克隆抗体作为Epo拮抗剂,观察其抑制红系增殖、分化和成熟的作用,为临床应用Epo抗体治疗高原红细胞增多症提供理论 Erythropoietin Epo is a major stimulator of growth, proliferation, differentiation and maturation of bone marrow erythroid progenitor cells and plays a key role in the pathogenesis of high altitude polycythemia (HAPC). In this paper, Epo polyclonal antibody was used as Epo antagonist to observe its role in inhibiting erythroid proliferation, differentiation and maturation, and to provide theory for the clinical application of Epo antibody in the treatment of high altitude polycythemia