细胞畸变是指细胞中遗传物质(染色体、基因)发生突然的和可遗传的变化,它与畸胎和肿瘤的发生具有密切的关系,这已为许多实验所证明。在研究化学污染物的致突变作用方面,可采用细胞体外培养方法,其优点是实验条件比之用整体动物实验容易控制,较易进行机制的探讨,可望在较短的期间内获得初步结果,因此现在已被广泛采用。细胞体外培养的致突实验方法很多,我们用细胞单层培养、染色体畸变实验和微核 Cell aberrations are sudden and heritable changes in the genetic material (chromosomes, genes) in cells. They are closely related to the occurrence of teratomas and tumors, which has been proved by many experiments. In the study of mutagenic effects of chemical contaminants, cell culture methods can be used, the advantage of the experimental conditions than the overall animal experiments easier to control, easier to explore the mechanism is expected to obtain preliminary results in a short period of time , It has now been widely adopted. In vitro cell mutagenesis experiments are many ways, we use cell monolayer, chromosome aberration experiment and micronucleus