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0.5mg/kg花生四烯酸从免耳缘静脉缓慢注入,成功地复制了可重复的肺栓塞肺动脉高压模型。抗血小板药阿魏酸钠对抗花生四烯酸升高肺动脉压,同时抑制花生四烯酸增加血小板聚集性及增加血浆血栓素A_2、前列环素水平的效应,并明显增加血浆环鸟苷酸水平。
0.5 mg / kg arachidonic acid slowly inflated from the limbus-free vein successfully replicated the model of pulmonary embolism with repeatable pulmonary embolism. Antiplatelet drug sodium ferulate against arachidonic acid increased pulmonary arterial pressure, while inhibiting arachidonic acid to increase platelet aggregation and increase plasma thromboxane A 2, prostacyclin levels, and significantly increased plasma levels of cGMP .