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溴苄铵的电生理作用,各家报道不一。为此,本文研究奎尼丁与溴苄铵的相互作用,藉以澄清其作用机理,并对观点不一致的原因作一解释。方法:用离体兔心作实验,给予灌注改良Chenoweth氏溶液作为对照,然后分别加用奎尼丁5毫克/升,及奎尼丁5毫克/升+溴苄铵20毫克/升,每次灌注至少持续30分钟。在灌注期间,于窦房结附近置一起搏电极,使心率维持在较窦性心率快10～15次/分;再用微电极自心房、房室连接处及心室纤维记录经膜电位,加以放大,录下图形。结果:(1)对心室纤维的作用:奎尼丁使0位相的最大除极速率自57.5±14.6伏/秒减至36.0±8.9伏/秒,并使动作电位时间自118±22.0毫秒延长至147.0±25.6毫
Bromobenzylamine electrophysiological effects, various reports vary. Therefore, this paper studies the interaction between quinidine and benzyl ammonium bromide in order to clarify its mechanism of action, and to explain the reasons for inconsistent views. Methods: In vitro rabbit hearts were used for experiments. The perfusion improved Chenoweth’s solution was used as a control. The animals were treated with quinidine 5 mg / l, quinidine 5 mg / l + bromobenzyl ammonium 20 mg / Perfusion for at least 30 minutes. During perfusion, a pacemaker electrode is placed near the sinoatrial node to maintain the heart rate 10 to 15 beats / min faster than the sinus heart rate; the membrane potential is recorded from the atria, atrioventricular junction, and ventricular fibers using a microelectrode, Zoom in, record the graphics. Results: (1) Effect on ventricular fibers: quinidine reduced the maximum depolarization rate of phase 0 from 57.5 ± 14.6 volts / second to 36.0 ± 8.9 volts / second and prolonged action potential time from 118 ± 22.0 ms 147.0 ± 25.6 milliliters