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直到最近,人们一直认为催产素只与射乳和宫缩有关。其实,从五十年代末起,就陆续发现催产素能缩短牛、绵羊和山羊的黄体生存期,加速动情期的开始。催产素还能促进子宫释放PGF_(2α)(有溶黄体作用)和在黄体将近退化时使子宫催产素受体的数目增加。抗催产素主动免疫能延长绵羊黄体生存期。以上研究支持催产素有调节黄体功能的假设。1982年发现绵羊、牛和人类黄体本身亦含高浓度的催产素。以PGF_(2α)类似物处理绵羊时,催产素可释人血循环。子宫切除或妊娠时,黄体合成催产素受阻,提示有一个子宫因子调节黄体中催产素的生成。在上述实验中,尚未将黄体中的催产素分离并定出其一级结构,但多方面证据表明,它确为催产素本身,或为与催产素结构非常
Until recently, it was believed that oxytocin was only associated with injection of milk and contractions. In fact, since the late 1950s, oxytocin has been gradually found to shorten the luteal survival of cattle, sheep and goats and speed up the beginning of estrus. Oxytocin also promotes uterine release of PGF 2α (with luteinizing effect) and increases the number of uterotrophic oxytocin receptors when corpus luteum is nearly degenerated. Anti-oxytocin active immunization can prolong the luteal survival of sheep. The above studies support the hypothesis that oxytocin regulates luteal function. In 1982, sheep, cattle and the human luteal mass itself were also found to contain high concentrations of oxytocin. Oxytocin is capable of releasing the bloodstream when sheep are treated with the PGF (2 [alpha]) analog. Hysterectomy or pregnancy, the synthesis of oxytocin luteal obstruction, suggesting that there is a uterine factor regulating the formation of oxytocin in the corpus luteum. In the above experiment, the luteal oxytocin has not yet been separated and its primary structure has been determined, but there is ample evidence that it is indeed oxytocin itself or very different from oxytocin