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目的:观察滋肾疏肝化痰调冲汤方对多囊卵巢综合征的临床疗效,并探讨其对胰岛素抵抗的影响。方法:将60例患者随机分为两组,每组30例,中西医结合治疗组(观察组)以滋肾疏肝化痰调冲汤联合达英35治疗,西药组(对照组)以达英-35治疗,治疗3个周期,观察用药前后患者体重指数(BMI),生殖激素(FSH、LH、T),用稳态模型计算胰岛素抵抗指数(Homa-IR=FPG×INS/22.5)的变化。结果:用药3个周期后①两组患者LH、T的水平均下降(P<0.05)②治疗组患者Homa-IR下降(P<0.05),对照组Homa-IR下降不明显(P>0.05)③治疗组BMI下降(P<0.05)。对照组BMI下降不明显(P>0.05)④两组肝肾功能均无异常。结论:中西医联合治疗多囊卵巢综合征胰岛素抵抗的疗效优于纯西药达英-35,且中药的毒副反应不明显。
Objective: To observe the clinical curative effect of Zishen Shugan Huatan tiao chong tang decoction on polycystic ovary syndrome and to explore its effect on insulin resistance. Methods: Sixty patients were randomly divided into two groups (n = 30 in each group). Integrative Chinese and western medicine treatment group (n = (BMI) and reproductive hormones (FSH, LH, T) were measured before and after treatment with the British -35 treatment and three cycles of treatment. The insulin resistance index (Homa-IR = FPG × INS / 22.5) Variety. Results: The levels of LH and T in both groups decreased after three cycles of treatment (P <0.05). The Homa-IR of the two groups decreased (P <0.05), and the Homa-IR of the control group did not decrease significantly ③ BMI decreased in treatment group (P <0.05). The decrease of BMI in the control group was not significant (P> 0.05) ④ There was no abnormal liver and kidney function in the two groups. Conclusion: The curative effect of combined treatment of Chinese and Western medicine on insulin resistance of PCOS is better than that of pure western medicine Ying-35, and the side effects of traditional Chinese medicine are not obvious.