下肢肌肉痛性痉挛,由部分或全部肌肉群不随意收缩所致,常见于老年腓肠肌和足部肌肉,多在夜间发作。该病硫酸奎宁有效,但可引起金鸡纳中毒。作者报告8例夜间卧位时小腿痉挛,年龄62～87岁(平均71.1)。睡前口服硫酸奎宁260mg,连续治疗8天不能控制。改服盐酸维拉帕米,每日睡前口服120mg。随访8周,夜间小腿痉挛发作明显减轻。作者指出,这是钙拮抗剂新用途的重要 Muscle cramps in the lower extremities are caused by involuntary contraction of some or all of the muscle groups commonly found in the gastrocnemius and foot muscles of the elderly and often during the night. The disease quinine sulfate effective, but can cause cinchona poisoning. The authors report eight cases of leg spasm during nighttime lying position, aged 62-87 years (mean, 71.1). Before going to bed oral quinine sulfate 260mg, 8 days continuous treatment can not be controlled. Change service verapamil hydrochloride, 120mg orally daily before going to bed. Followed up for 8 weeks, the incidence of leg spasm was significantly reduced at night. The authors point out that this is an important new use of calcium antagonists