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法莫替丁(Famotidine)是一种高效组胺H_2受体拮抗剂,睡前服40mg可使整夜胃酸下降,白天则恢复正常,但食后血浆胃泌素浓度却明显上升。许多研究表明组胺H_2受体拮抗剂和亚砜味唑使胃酸减少,而血浆胃泌素浓度却上升。大鼠服大剂量亚砜咪唑2年可导致胃类癌。进一步实验发现由抗分泌药或五肽胃泌素诱导产生的血浆胃泌素升高将伴有ECL细胞(嗜铬细胞)增多。
Famotidine is a potent histamine H 2 receptor antagonist. Pre-nalpine 40 mg reduces gastric acid throughout the night and returns to normal during the day, but plasma gastrin levels rise significantly after the meal. Numerous studies have shown that histamine H 2 receptor antagonists and sulfoximine reduce gastric acidity and increase plasma gastrin levels. Rats serving large doses of sulfoximine for 2 years can cause stomach cancer. Further experiments revealed that the increase of plasma gastrin induced by antisecretory drugs or pentagastrin would be associated with an increase in ECL cells (chromaffin cells).