大肠癌作为世界范围内最常见的恶性肿瘤之一,随着现代分子生物学及基因工程技术的发展,肿瘤的基因治疗成为近年来的研究热点。大肠癌的基因治疗作为一种新的治疗手段,近年来倍受关注。本文综述了癌基因和抑癌基因、免疫基因、自杀基因、抗肿瘤血管基因、溶瘤病毒及联合治疗大肠癌新研究进展。 As one of the most common malignant tumors in the world, with the development of modern molecular biology and genetic engineering, gene therapy of tumors has become a hot spot in recent years. As a new treatment of colorectal cancer gene therapy, much attention in recent years. This review summarizes recent advances in oncogenes and tumor suppressor genes, immune genes, suicide genes, anti-tumor vascular genes, oncolytic viruses and combination therapy of colorectal cancer.