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目的 :探讨糖尿病肾病患者尿液转化生长因子 β1 ( TGFβ1 )的变化及其与糖尿病肾病发生发展的关系。方法 :采用酶联免疫吸附法检测 84例 2型糖尿病患者和 2 4例正常人尿液 TGFβ1水平。结果 :2型糖尿病 ( DM)患者尿液 TGFβ1水平 [( 7.99± 1 4.37) ng/L]明显高于正常对照组 [( 2 .95± 2 .5 1 ) ng/L,P<0 .0 1 ];DM各组间尿液 TGFβ1比较显示微量和大量白蛋白尿期患者尿液 TGFβ1水平 [( 1 4.45± 2 2 .2 4 ) ng/L、( 1 3.68± 1 8.97) ng/L ]比正常白蛋白尿期患者 [( 3.5 9± 1 .87) ng/L]明显升高 ( P均 <0 .0 5 ) ,但此两组间无显著性差异 ( P>0 .0 5 ) ;病程超过 5年者尿液 TGFβ1显著高于病程短于 5年者 ;尿液 TGFβ1与糖化血红蛋白、UAE等无相关。结论 :糖尿病肾病 ( DN)患者尿液 TGFβ1水平升高 ,尿液TGFβ1水平与 DN的发生有关 ,尿液 TGFβ1可作为 DN早期诊断的指标
Objective: To investigate the changes of urine transforming growth factor β1 (TGFβ1) and its relationship with the development of diabetic nephropathy in patients with diabetic nephropathy. Methods: Urinary TGFβ1 levels in 84 type 2 diabetic patients and 24 normal individuals were detected by enzyme-linked immunosorbent assay. Results: Urine TGFβ1 levels in patients with type 2 diabetes were significantly higher than those in controls ([(7.99 ± 1.43) ng / L] [(2.95 ± 2.51) ng / L, P < 1]. Urine TGFβ1 in DM patients showed a significant difference in urinary TGFβ1 levels between the groups of micro- and macroalbuminuria [(1.45 ± 2.22.4 ng / L, (1.68 ± 1.897) ng / L] (3.59 ± 1.87) ng / L] in patients with normal albuminuria (all P <0.05), but there was no significant difference between the two groups (P> 0.05) ; Urine TGFβ1 was significantly higher than the course of more than 5 years in less than 5 years; Urine TGFβ1 and glycosylated hemoglobin, UAE no correlation. Conclusion: Urine TGFβ1 levels in diabetic nephropathy (DN) patients and urinary TGFβ1 levels correlate with the occurrence of DN. Urine TGFβ1 may be used as an indicator of early diagnosis of DN