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目的 探讨一氧化氮 (NO)在虹膜睫状体炎发病中的作用。方法 应用硝酸还原酶法测定 4 2例虹膜睫状体炎患者血浆NO浓度 (其中 12例为强直性脊椎炎者 ) ,以 30例健康志愿者为对照。结果 急性虹膜睫状体炎患者不伴强直性脊椎炎者其血浆NO含量明显增高 (30 5 .3± 2 2 .5 1) μmol/L ,与正常对照组NO浓度 (6 3.2± 11.5 ) μmol/L有显著性差异 (P <0 .0 1) ;病情恢复期 ,NO水平明显下降 (6 8.6± 12 .6 ) μmol/L与对照组比较无显著性差异 (P >0 .0 5 ) ,急性期与恢复期NO浓度有显著性差异 (P <0 .0 1)。伴强直性脊椎炎的虹膜睫状体炎患者NO水平为 (32 2 .6± 2 4 .4 7) μmol/L ,与正常对照组有显著性差异 (P <0 .0 1) ;该组虹膜睫状体炎炎症消退后 ,NO水平仍较高 (2 83.6± 19.2 ) μmol/L ,与正常对照组有显著性差异 ,(P <0 .0 1)。 结论 NO参与了虹膜睫状体炎及强直性脊椎炎的发病 ,提示可通过调节NO的生成 ,从而控制炎症过程 ,为临床治疗虹膜睫状体炎及强直性脊椎炎提供了新思路。
Objective To investigate the role of nitric oxide (NO) in the pathogenesis of iridocyclitis. Methods Nitric acid reductase method was used to determine plasma NO concentration in 42 patients with iridocyclitis (12 of them were ankylosing spondylitis) and 30 healthy volunteers as control. Results In patients with acute iridocyclitis, the plasma NO levels were significantly increased (30 5 .3 ± 2 2 .5 1) μmol / L in patients without ankylosing spondylitis, compared with those in normal controls (6 3.2 ± 11.5) μmol / L had significant difference (P <0.01); NO level decreased significantly during recovery (6 8.6 ± 12.6 μmol / L) compared with the control group (P> 0.05) , There was a significant difference in NO concentration between acute phase and convalescent phase (P <0.01). The level of NO in iridocyclitis with ankylosing spondylitis was (32.2 ± 6.24.47) μmol / L, which was significantly different from the normal control group (P <0.01) After the inflammation of iridocyclitis subsided, the NO level was still high (2 83.6 ± 19.2) μmol / L, which was significantly different from the normal control group (P <0.01). Conclusions NO participates in the pathogenesis of iridocyclitis and ankylosing spondylitis, suggesting that NO can regulate the process of inflammation by controlling the production of nitric oxide and provide a new idea for the treatment of iridocyclitis and ankylosing spondylitis.