动态观察博莱霉素致肺间质纤维化大鼠的支气管肺泡灌洗液中细胞总分数、肺泡巨噬细胞培养上清中纤维连接蛋白含量的变化及肺脏病理改变，并以秋水仙碱进行体内干预。结果：模型组在疾病早期的支气管肺泡灌洗液中细胞总数、中性粒细胞及肺泡巨噬细胞培养上清纤维连接蛋白含量明显增高；药物干预组支气管肺泡灌洗液的细胞总数，中性粒细胞及纤维连接蛋白含量较模型组明显降低。提示：秋水仙碱可能对纤维连接蛋白的形成产生影响。 Dynamic observation of bleomycin-induced pulmonary fibrosis rats bronchoalveolar lavage fluid total score, alveolar macrophage cell culture supernatant fibronectin content changes and pathological changes of the lungs, and colchicine In vivo intervention. Results: In the model group, the total number of cells in the bronchoalveolar lavage fluid and the content of fibronectin in the culture supernatant of alveolar macrophages were significantly increased in the early stage of the disease. The total number of bronchoalveolar lavage fluid cells in the model group, Granulocyte and fibronectin levels were significantly lower than the model group. Tip: Colchicine may have an effect on fibronectin formation.