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目的探讨奥曲肽联合奥美拉唑治疗肝硬化并发上消化道出血的临床效果及护理体会。方法选择2014年6月至2016年6月于我院住院的肝硬化并发上消化道出血的患者82例,随机分为对照组41例,给予垂体后叶素联合奥美拉唑治疗;观察组41例,给予奥曲肽联合奥美拉唑治疗;观察2组患者住院天数、并发症、平均止血时间以及肝功能变化。结果观察组在住院天数、并发症、平均止血时间变化明显优于对照组,差异有统计学意义(P<0.05);2组出院时肝功能指标较入院时好转,观察组肝功能改善明显优于对照组,差异有统计学意义(P<0.05)。结论奥曲肽联合奥美拉唑治疗肝硬化并发上消化道出血临床疗效显著,能明显改善患者肝功能,具有协同作用,值得临床推广。
Objective To investigate the clinical effects and nursing experience of octreotide combined with omeprazole in the treatment of cirrhosis complicated with upper gastrointestinal bleeding. Methods Eighty-two patients with cirrhosis and upper gastrointestinal bleeding hospitalized in our hospital from June 2014 to June 2016 were randomly divided into control group (n = 41) and pituitrin combined with omeprazole (n = 28). The observation group 41 cases were treated with octreotide combined with omeprazole. The days of hospitalization, complications, mean hemostasis time and changes of liver function were observed. Results The changes of days, complications and mean hemostasis time in the observation group were significantly better than those in the control group (P <0.05). The indexes of liver function in the two groups were better than those at admission, and the improvement of liver function in the observation group was better In the control group, the difference was statistically significant (P <0.05). Conclusion The clinical efficacy of octreotide combined with omeprazole in the treatment of cirrhosis complicated with upper gastrointestinal bleeding is significant. It can significantly improve the liver function of patients with synergistic effects and is worthy of clinical promotion.