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目的 探讨鼻咽癌（ＮＰＣ）患者全血硒和谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）水平与健康人的差别，以及与肿瘤临床分期之间的关系。 方法 对１２２ 例ＮＰＣ患者采用２．３－二氨基萘（ＤＮ）荧光法测定血硒，采用２－硝基苯甲酸直接显色法测定血ＧＳＨ－ＰＸ水平，并设健康人对照；数据采用ｔ检验及方差分析进行统计学处理。 结果 （１）放疗前ＮＰＣ患者血硒和ＧＳＨ－ＰＸ水平均低于对照组（Ｐ＜ ０．０１）。（２）随着临床分期的增加，血硒和ＧＳＨ－ＰＸ水平逐渐下降，（Ｐ＜ ０．０１）。（３）放疗后患者血硒和ＧＳＨ－ＰＸ水平比放疗前升高，但仍比对照组低（Ｐ＞ ０．０５）。 结论 （１）ＮＰＣ患者血硒和ＧＳＨ－ＰＸ均处于低水平状态。（２）血硒和ＧＳＨ－ＰＸ水平与ＮＰＣ的发生、发展可能有关。
Objective To investigate the differences of serum levels of selenium and glutathione peroxidase (GSH-PX) in healthy volunteers from patients with nasopharyngeal carcinoma (NPC) and their relationship with clinical stage. Methods Seventy-two patients with NPC were tested for serum selenium by fluorescence spectrophotometry with 2.3-diaminonaphthalene (DN), GSH-PX levels were measured by 2-nitrobenzoic acid direct colorimetric method, and healthy controls were used. Data were analyzed using t Test and analysis of variance for statistical analysis. Results (1) The levels of serum selenium and GSH-PX in NPC patients before radiotherapy were lower than those in the control group (P <0.01). (2) Serum selenium and GSH-PX levels gradually decreased with the increase of clinical stage (P <0.01). (3) The levels of blood selenium and GSH-PX in patients after radiotherapy were higher than those before radiotherapy, but still lower than those in control group (P> 0.05). Conclusions (1) Selenium and GSH-PX in NPC patients are in a low level. (2) Serum selenium and GSH-PX levels may be related to the occurrence and development of NPC.