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目的 :为观察小儿难治性肾病 ( RNS)的临床与病理改变之间的关系。 方法 :对 2 1例符合诊断的住院患儿的病理诊断及临床类型、临床疗效进行了分析。 结果 :小儿难治性肾病的病理类型中以系膜增殖型肾小球肾炎( Ms PGN )多见 ( 8/ 2 1) ,其次为微小病变型肾小球肾炎 ( MCNS) ( 5 / 2 1)、局灶节段性肾小球硬化 ( FSGS) ( 4/ 2 1) ;临床表现为 FR/ SD者 ,MCNS为 5 / 5 ,Ms PGN为 7/ 8,FSGS为 1/ 4;临床疗效中 ,获完全缓解者 ,MCNS为 4/ 5 ,Ms PGN为 6 / 8,FSGS为 0 / 4。 结论 :小儿难治性肾病病理改变以 MCNS、Ms PGN及 FSGS较多见 ,而 MCNS及Ms PGN多表现为 FR/ SD型、且较易获得完全缓解 ,FSGS者以 SR型多见 ,且治疗难度较大
Objective: To observe the relationship between clinical and pathological changes in children with refractory renal disease (RNS). Methods: The pathological diagnosis, clinical type and clinical efficacy of 21 inpatients with inpatient diagnosis were analyzed. Results: Among the pathological types of refractory nephropathy in children, mesangial proliferative glomerulonephritis (Ms PGN) was more common (8/2 1), followed by minimal lesion glomerulonephritis (MCNS) ), Focal segmental glomerulosclerosis (FSGS) (4/2 1). The clinical manifestations were FR / SD, MCNS was 5/5, Ms PGN was 7/8 and FSGS was 1/4. Among those with complete remission, MCNS was 4/5, Ms PGN was 6/8 and FSGS was 0/4. Conclusion: The pathological changes of refractory nephropathy in children are more common in MCNS, Ms PGN and FSGS, and MCNS and Ms PGN are mostly FR / SD type, and are easier to obtain complete remission. FSGS are more common in SR type and treatment More difficult