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本文观察28例慢性充血性心力衰竭的心肌痛患者,评价硝酸盐对其心排出量和左室流出道阻力的影响。其中22例分别用可含嚼的二硝异山梨醇脂5～20mg,口服二硝酸异山梨醇脂30～40mg或外用硝酸甘油软膏33mg。在药物高峰作用期测定平均动脉压、左室充盈压、体循环血管阻力和心脏指数。另6例则先用止血带,再静脉滴注硝普钠,然后再给予含嚼二硝酸异山梨醇脂,分别在三者的高峰作用期测定上述血流动力学的参数,并比较它们在血流动力学上的作用。
In this paper, 28 patients with chronic heart failure and heart failure were observed to evaluate the effect of nitrate on cardiac output and left ventricular outflow tract resistance. Of which 22 cases were chewable with isosorbide dinitrate 5 ~ 20mg, oral isosorbide dinitrate 30 ~ 40mg or topical nitroglycerin ointment 33mg. Mean arterial pressure, left ventricular filling pressure, systemic vascular resistance, and cardiac index were measured during the peak period of the drug. The other 6 patients were treated with tourniquets, sodium nitroprusside intravenously and then with isosorbide dinitrate, respectively. The parameters of hemodynamics were measured during the peak period of the three and compared with Hemodynamic effects.