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药物的溶解度、稳定性、安全性等都与pH有关,所以注射液应规定pH在一定范围。不同产品规定范围不同,同一产品因批次不同pH各异,以致某些药物配伍使用时,出现混浊、沉淀、效价降低或失效等问题。但遗憾的是,注射液都未标明pH。据报道,10%葡萄糖注射液pH为3.37或3.20时,与清开灵注射液配伍,药液分别为澄清和混浊两种现象,头孢唑啉钠的水溶液在pH4.0～7.5较稳定,pH>8或<4时不稳定,水解速度加快;其1g溶于生理盐水50ml或100ml时,pH低于3.5即析出结
Drug solubility, stability, safety and so on are related to the pH, so the injection should be specified in a certain pH range. Different products have different scope, the same product due to different batches of different pH, resulting in the use of certain drugs compatibility, appear turbidity, precipitation, potency reduction or failure and other issues. Unfortunately, none of the injections indicated pH. It was reported that 10% glucose injection pH 3.37 or 3.20, and Qingkailing injection compatibility, the liquid were clarified and turbid two phenomena, cefazolin sodium aqueous solution at pH4.0 ~ 7.5 more stable, pH > 8 or <4 instability, hydrolysis speed; 1g dissolved in saline 50ml or 100ml, pH below 3.5 that is, precipitation