论文部分内容阅读
目的:研究注射用参麦皂苷(SMI)的抗应激性以及对心肌缺血的保护作用。方法:分别通过小鼠常压耐缺氧实验、急性脑缺氧实验和负重游泳实验,考察了SMI对小鼠应激性的影响;采用舌静脉注射垂体后叶素造成大鼠急性心肌缺血模型,观察SMI对模型大鼠心电图指标及心率的影响,考察SMI对大鼠心肌缺血的保护作用。结果:与对照组比较,SMI 2.6mg/kg、5.2mg/kg和10.4mg/kg剂量组均能延长常压耐缺氧实验小鼠的存活时间、快速断头后小鼠的张口喘气时间及小鼠负重游泳的时间;并且与模型组比较,SMI 1.8mg/kg、3.6mg/kg和7.2mg/kg剂量组均可显著减轻垂体后叶素所引起大鼠的心电图J点位移、T波高度的改变。结论:SMI能提高小鼠的应激能力,并对垂体后叶素诱发的大鼠急性心肌缺血具有保护作用。
OBJECTIVE: To study the anti-stress and the protective effect of SMI on myocardial ischemia. Methods: The effects of SMI on stress in mice were investigated by hypoxia tolerance test, acute cerebral hypoxia test and swimming load-bearing test respectively. Injection of pituitrin into the tongue resulted in acute myocardial ischemia Model to observe the impact of SMI on ECG parameters and heart rate of rat model to investigate the protective effect of SMI on myocardial ischemia in rats. Results: Compared with the control group, SMI 2.6mg / kg, 5.2mg / kg and 10.4mg / kg dose groups could prolong the survival time of hypoxia-tolerant mice, the mouth-breathing time of mice after rapid decapitation and The weight of swimming time in the mice; And compared with the model group, SMI 1.8mg / kg, 3.6mg / kg and 7.2mg / kg dose group can significantly reduce the pituitrin induced ECG J point displacement, T wave Height change. Conclusion: SMI can improve the stress ability of mice and protect the rat myocardium induced by pituitrin.