1997年至1999年期间作者治疗5例急性淋巴细胞白血病患者,由于应用大剂量甲氨喋呤而致明显的皮肤,粘膜损害,现分析报告如下: 临床资料 5例中男性2例,女性3例,年龄16～42岁。应用的甲氨喋呤均为奥地利依比威大药厂生产。甲氨喋呤剂量:1～1.5g/M~2,总量为1.6～2.4g。用法:加入2000ml葡萄糖液体中分四次持续24小时静点,用药结束后12小时用四氨叶酸钙注射液 The author from 1997 to 1999 five cases of acute lymphoblastic leukemia patients, due to the application of large doses of methotrexate caused significant skin and mucosal damage, the report is as follows: 5 cases of clinical data in 2 males and 3 females , Aged 16 to 42 years old. Methotrexate used are all manufactured at the Ausbildung Pharmacy in Austria. Methotrexate dose: 1 ~ 1.5g / M ~ 2, the total amount of 1.6 ~ 2.4g. Usage: add 2000ml glucose solution in four points for four hours after the static point, 12 hours after the end of the medication with calcium tetraamine folic acid injection