Jones试剂(26.72 g铬酐溶于含有23 ml浓硫酸的水溶液中,用水稀释到100 ml)可将仲醇氧化为酮,伯醇氧化为羧酸。作者在用Jones试剂氧化化合物(1c)以获得化合物(2b)时,意外地发现主产物是化合物(2c)。鉴于这一异常反应的出现,我们对具有4-烯-3~-酮结构的甾体化合物17β,19位羟基Jones试剂氧化产物作了研究。 用Jones试剂氧化化合物(1a)或(1b),分别得到 Jones reagent (26.72 g of chromic anhydride in an aqueous solution containing 23 ml of concentrated sulfuric acid and diluting to 100 ml with water) can oxidize the secondary alcohol to a ketone, which is oxidized to a carboxylic acid. When the author oxidized the compound (1c) with Jones reagent to obtain the compound (2b), it was unexpectedly found that the main product was the compound (2c). In view of the occurrence of this abnormal reaction, we have studied the oxidation products of 17β, 19-hydroxy-Jones reagent with 4-ene-3-keto structure. Compound (1a) or (1b) is oxidized with Jones reagent to obtain respectively