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丹参素是从丹参的水溶性酚性酸中提取出的R(+)-3,4-二羟基苯基乳酸的钠盐。它是丹参水溶性成分中抗心肌缺血的主要成分,有扩张血管、增加冠脉流量等作用。仅从丹参植物中提取有效成分有局限性,同时丹参素的结构极易氧化,因此薛芬,董纪昌等改进合成了消旋的丹参素和几个取代苯基乳酸。从中筛选到苯基乳酸有较强抑制血小板聚集和抑制微循环障碍的作用,现正进行临床药理试验。
Danshensu is a sodium salt of R (+) - 3,4-dihydroxyphenyllactate extracted from water-soluble phenolic acids of Salvia miltiorrhiza. It is the main component of anti-myocardial ischemia in Salvia miltiorrhiza water-soluble ingredients, such as dilating blood vessels and increasing coronary flow. Only from the Salvia extract active ingredients have limitations, while the structure of Danshensu very easily oxidized, so Xue Fen, Dong Jichang and other improved synthesis of racemic Danshensu and several substituted phenyl lactic acid. From the screening of phenyl lactic acid has a strong inhibition of platelet aggregation and inhibition of microcirculation, the ongoing clinical pharmacology trials.