本文报导两侧长期应用锂盐治疗,药物耐受性一直良好,治疗效果也持续满意的病人最后却出现了严重的不可逆性的小脑损害。病例一为42岁女性患者,以意识模糊状态逐惭加深而急诊入院。病人有20年躁狂抑郁精神病发作史。近两年来持续服用锂盐治 This article reports the long-term application of lithium salts on both sides of the long-term treatment, drug tolerance has been good, the treatment effect is also continuing satisfactory patients eventually appeared a serious irreversible cerebellar damage. Case 1 was a 42-year-old female patient admitted to the hospital in an ambiguous state of deepening deepening. The patient has a history of 20 manic depression and psychosis. Over the past two years to take lithium salt treatment