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过去利用实验动物所做的研究,证明氨基糖苷类抗生素在与非离子表面活性剂同时给药时,可增强其胃肠道吸收。本文报道对健康的受试者经由鼻道给予艮他霉素和表面活性剂甘胆酸钠的混合溶液时,可增强抗生素的吸收。7名志愿受试者(5名男子和2名妇女)均健康良好,未接受过其它药物治疗。他们的
Past studies using experimental animals have demonstrated that aminoglycoside antibiotics enhance their gastrointestinal absorption when co-administered with non-ionic surfactants. This article reports that antibiotic absorption can be enhanced when a mixed solution of gentamicin and surfactant sodium glycocholate is administered nasally to healthy subjects. Seven volunteer subjects (five men and two women) were healthy and had not received any other medical treatment. Their