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许多疾病具有微循环缺血缺氧、炎症因子浸润、组织增生的特点,这可以被看作“瘀血阻络”的微观表征,在治疗上常运用以桂枝茯苓丸为代表的化瘀通络的名方,如盆腔炎、子宫肌瘤[1]的治疗。国内外多认为其药理作用与降低血液黏度、全血高切比黏度及凝血因子浓度等血流变学指标有关[2],随着研究的深入,中药化瘀通络作用的研究也逐渐进入分子水平,学者们发现缺氧是VEGF最强的刺激因子,VEGF是缺氧活化的HIF-1的下游靶基因之一[3],因而发现中药化瘀通络的作用与其对VEGF的调控有相关性,这为临床运用化瘀通络法治疗具有VEGF表达失调特点的疾病提供了理论支撑。
Many diseases have the characteristics of microcirculation ischemia and hypoxia, infiltration of inflammatory factors, tissue proliferation, which can be seen as “blood stasis network,” the microscopic characterization, often used in the treatment of Guizhi Fuling pill represented The name of stasis Tongluo, such as pelvic inflammatory disease, uterine fibroids [1] treatment. At home and abroad and more that its pharmacological effects and reduce blood viscosity, high blood viscosity and whole blood clotting factor concentration and other indicators of hemorheology [2], with the in-depth study of the role of traditional Chinese medicine Huayu meridian gradually into Molecular level, scholars found that hypoxia is the strongest VEGF stimulating factor, VEGF is hypoxia-activated HIF-1 downstream target genes [3], and found that the role of traditional Chinese medicine and its regulation of VEGF with This provides a theoretical support for the clinical application of the method of removing blood stasis and collaterals to treat the diseases characterized by the imbalance of VEGF expression.