嗜中性白细胞吞噬并杀死摄入菌的能力对哺乳动物抵抗病原菌起关键作用。最近从强毒牛种布氏菌表面分离出核甙酸成份,它能抑制牛嗜中性白细胞的蛋白质碘化作用。本文目的在于检查分离自牛种布氏菌的核甙酸类物抑制牛嗜中性白细胞的脱颗粒作用的能力,以及测定初级或次级颗粒从嗜中性白细胞中释放时是否存在早期抑制作用。 The ability of neutrophils to engulf and kill ingested bacteria plays a key role in mammalian resistance to pathogens. The recent isolation of nucleotides from the brucella surface of virulent brucellosis inhibited the protein iodination of bovine neutrophils. The purpose of this document is to examine the ability of nucleolar isolates isolated from B. bovinus to inhibit the degranulation of bovine neutrophils and to determine whether early or early inhibitory effects are present when primary or secondary particles are released from neutrophils .