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目的 :探讨 nm2 3基因产物与膀胱移行细胞癌生物学行为之间的关系。方法 :应用免疫组织化学方法检测 45例膀胱移行细胞癌组织 nm2 3基因表达。结果 :蛋白弥散于胞浆及胞膜 ,nm2 3蛋白表达与膀胱癌分级呈正相关 ,但与分期无关 ,有转移性癌组织 nm2 3表达明显高于无转移癌组织 (P<0 .0 1 )。结论 :nm2 3基因表达对于判断膀胱移行细胞癌的恶性程度是一个有价值的指标。
Objective: To investigate the relationship between the nm23 gene product and the biological behavior of bladder transitional cell carcinoma. Methods: Immunohistochemistry was used to detect the expression of nm23 gene in 45 cases of bladder transitional cell carcinoma. Results: There was a positive correlation between the expression of nm23 protein and the grade of bladder cancer, but the expression of nm23 in metastatic carcinoma was significantly higher than that in non-metastatic carcinoma (P <0.01) . Conclusion: The expression of nm23 gene is a valuable index for judging the malignant degree of bladder transitional cell carcinoma.