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目的:分析氟喹诺酮类药物严重不良反应。方法:收集2009-2011年武汉市食品药品监督管理局药品不良反应报告数据库中的喹诺酮类药不良反应报告1 315例,从中筛选出的23例氟喹酮药严重不良反应报告进行统计分析。结果:23例严重ADR涉及7种临床常用氟喹酮类药,其中以左氧氟沙星的ADR比例最高。不良反应涉及到全身、神经、循环、呼吸、泌尿、皮肤及附件多器官多系统。口服、注射给药均可发生过敏性休克,过敏性休克发生时间一般在30min内,其中1例发上在用药后30 s。老年人ADR构成比较高。结论:应高度重视氟喹酮药物的严重不良反应,提高对该类药的安全用药的意识。
Objective: To analyze the serious adverse reactions of fluoroquinolones. Methods: A total of 1 315 cases of quinolone adverse reactions in the adverse drug reaction report database of Wuhan Food and Drug Administration were collected from 2009 to 2011, and 23 cases of serious adverse reactions of fluoroquinolone were screened out for statistical analysis. Results: Twenty-three serious ADRs involved seven commonly used fluoroquinolones, of which the highest ADR was levofloxacin. Adverse reactions involving the whole body, nerves, circulation, respiration, urinary, skin and accessories multiple systems of multiple systems. Oral, injection administration can occur anaphylactic shock, anaphylactic shock occurs generally within 30min, of which 1 case of hair on the medication after 30s. ADR elderly constitute relatively high. CONCLUSIONS: Serious adverse reactions of florfenacil should be attached great importance and awareness of the safety of these drugs should be raised.