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本文研究多噻烷对大鼠肝脏微粒体和胞质中尿苷二磷酸葡萄糖醛酸转移酶、谷胱苷肽S转移酶、脱甲基酶和细胞色素P-450活性的影响，以及多噻烷经P-450体外代谢产物对小鼠经口急性毒性。结果表明染毒剂量为25和50mg／kg体重的多噻烷能不同程度地诱导上述酶类，酶活性为对照组的1.07～1.66倍。多噻烷体外代谢产物对小鼠的经口LD_(50)为1513.6mg／kg，属低毒，远低于多噻烷本身对小鼠的经口LD_(50)(145.8mg/kg)。
In this paper, the effects of polythiazine on the activities of uridine diphosphate glucuronosyltransferase, glutathione S-transferase, demethylase and cytochrome P-450 in rat liver microsome and cytoplasm, Alkaloid Acute Toxicity to Mice via P-450 In Vitro Metabolites. The results showed that polythiazine with 25 and 50 mg / kg body weight induced different degrees of enzyme activity, the enzyme activity was 1.07 ~ 1.66 times that of the control group. The oral LD50 of polythiazine was 1513.6mg / kg, which was lower than the oral LD50 (145.8mg / kg) of polythiane in mice.