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采用小白鼠扭体法和热板法进行了口服氯胺酮镇痛的实验研究。结果表明，口服氯胺酮对醋酸所致小白鼠腹腔疼痛有显著的止痛效果；对热刺激足底所致小鼠疼痛也能提高其痛阈值，但所用氯胺酮剂量委相应增加（１００ｍｇ／ｋｇ）。毒性实验结果表明，大鼠连续服用氯胺酮９０ｄ后，８０、４０、２０ｍｇ／ｋｇ３个剂量组与对照组（每组１０只）比较，大鼠外观行为无异常，健康存活，体重增加，血常规，心电图，肝、肾功能无异常，脑、肝、肾、心、肺病理学检查无异常发现，认为氯胺酮较长期服用是安全的。
An experimental study of oral ketamine analgesia was conducted by using writhing method and hot plate method in mice. The results showed that oral ketamine had a significant analgesic effect on acetic acid induced abdominal pain in mice and pain threshold in mice stimulated by heat stimulus. However, ketamine dose increased 100 mg / kg. Toxicity test results showed that rats in continuous dose of ketamine 90d, 80,40,20 mg / kg 3 dose group compared with the control group (10 mice per group), the appearance behavior of rats without abnormalities, healthy survival, weight gain, blood, ECG, liver and kidney function without abnormalities, brain, liver, kidney, heart, lung pathology examination found no abnormality, that ketamine longer-term use is safe.