背景运动耐受不良是射血分数正常心力衰竭老人(HFPEF)的主要症状,其机制及治疗所知甚少。方法及结果71例稳定的老年(70±1岁)血压己控制的代偿性HFPEF病人(80%为妇女)随机分入enalapril 20mg/d及安慰剂两组,双盲,随访12个月。评估运动氧耗峰值、6 min步行试验、Minneseter Living with HF问询、MRI、Doppler超声心动图和血管超声。计算药片数说明病人遵医嘱服药极好(94%)。Enalapril组25例,安慰剂组34例完成12个月的随访。随访 Background Motor tolerance is a major symptom of HFPEF, with poorly understood mechanisms and treatment. Methods and Results 71 stable elderly hypertensive (70 ± 1 years old) compensated HFPEF patients (80% of women) were randomized to enalapril 20 mg / day and placebo in a double-blind, 12-month follow-up. Assess peak exercise oxygen consumption, 6 min walk test, Minneseter Living with HF inquiry, MRI, Doppler echocardiography and vascular ultrasound. Calculating the number of tablets shows that the patient prescribed medication excellent (94%). Twenty-five patients in the Enalapril group and 34 in the placebo group completed a 12-month follow-up. Follow-up