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目的研究不同剂量的甲泼尼龙对慢性阻塞性肺疾病急性发作期的治疗效果。方法随机选取杞县中心医院2012年6月至2013年6月接诊的42例慢性阻塞性肺疾病急性发作期的患者并进行分组,实验组21例采用120 mg/d剂量的甲泼尼龙进行治疗,对照组21例采用90 mg/d的甲泼尼龙进行治疗。在患者接受治疗后第3、7天分别进行动脉血气分析和呼吸困难评分,检测患者的血糖和肝、肾功能。结果实验组患者在各方面的表现均比对照组有较大改善。实验组显效率为57.1%,有效率为28.5%,总有效率为85.6%;而对照组显效率为33.3%,有效率为42.8%,总有效率为76.1%。结论采用不同剂量的甲泼尼龙进行治疗,在疗效方面差异有统计学意义,采用120 mg/d的剂量对慢性阻塞性肺疾病急性发作期的治疗效果较好,有临床推广价值。
Objective To study the effect of different doses of methylprednisolone on acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 42 patients with acute exacerbation of chronic obstructive pulmonary disease from June 2012 to June 2013 in Qixian Central Hospital were randomly selected and divided into groups. In the experimental group, 21 patients were treated with methylprednisolone at a dose of 120 mg / d In the control group, 21 cases were treated with methylprednisolone (90 mg / d). Arterial blood gas analysis and dyspnea score were performed on the 3rd and 7th day after treatment, and the blood glucose, liver and kidney function were measured. Results The performance of the experimental group in all aspects than the control group have been greatly improved. The effective rate was 57.1% in the experimental group, the effective rate was 28.5%, the total effective rate was 85.6%; while in the control group, the effective rate was 33.3%, the effective rate was 42.8% and the total effective rate was 76.1%. Conclusion Different doses of methylprednisolone treatment have statistically significant differences in curative effect. The 120 mg / d dose has a good curative effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease and has clinical value of promotion.