论文部分内容阅读
目的探讨抽动障碍患儿血铅水平变化对脑电活动的影响及其发病机制的研究,对比不同血铅水平患儿脑电图变化的特点。方法对本院2005年1月-2011年4月临床确诊的432例抽动障碍患儿进行血铅水平及脑电图检测。采用原子吸收光谱分析法测定其血铅水平,并进行t检验。将432例抽动障碍患儿分为3组,Ⅰ组:血铅水平<50μg.L-1;Ⅱ组:血铅水平50～100μg.L-1;Ⅲ组:血铅水平>100μg.L-1。结果 1.Ⅰ组患儿脑电图异常发生率为7.14%(2/28例),Ⅱ组患儿脑电图异常发生率为14.23%(40/281例),Ⅲ组患儿脑电图异常发生率为46.34%(57/123例)。Ⅰ组与Ⅱ组脑电图异常发生率比较差异无统计学意义(P>0.05),Ⅰ组与Ⅲ组脑电图异常发生率比较差异有统计学意义(P<0.01),Ⅱ组与Ⅲ组脑电图异常发生率比较差异有统计学意义(P<0.01)。2.除年龄≤4岁患儿外,脑电图异常患儿较脑电图正常患儿血铅水平明显升高(P<0.01,0.05)。结论血铅水平升高会加重抽动障碍患儿的脑功能损伤。及早进行驱铅治疗可能对抽动障碍患儿脑功能损伤的恢复有重要意义。
Objective To investigate the effect of changes of blood lead levels on EEG activity and its pathogenesis in children with tic disorder, and to compare the changes of EEG in children with different levels of lead. Methods A total of 432 children with tic disorder diagnosed in our hospital from January 2005 to April 2011 were tested for blood lead level and electroencephalogram. Blood lead levels were determined by atomic absorption spectrometry and t test. 432 children with tic disorder were divided into three groups: group Ⅰ: blood lead level <50μg.L-1; group Ⅱ: blood lead level 50-100μg.L-1; group Ⅲ: blood lead level> 100μg.L- 1. Results 1. The incidence of EEG abnormality in children withⅠgroup was 7.14% (2/28 cases), the incidence of EEG abnormality in groupⅡwas 14.23% (40/281 cases), and the electrocardiogram The abnormal incidence was 46.34% (57/123 cases). There was no significant difference in the incidence of EEG abnormalities in group Ⅰ and group Ⅱ (P> 0.05). The difference of EEG abnormalities in group Ⅰ and group Ⅲ was statistically significant (P <0.01) Group EEG abnormalities were significantly different (P <0.01). Except children younger than 4 years old, the level of blood lead in children with EEG abnormalities was significantly higher than that in children with normal EEG (P <0.01, 0.05). Conclusion The elevated blood lead may aggravate the brain dysfunction in children with tic disorder. Early withdrawal of lead may have important implications for the recovery of impaired brain function in children with tic disorders.