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孕酮(P)参与卵泡破裂一系列过程,实验提示P能增加卵泡壁的伸展性,垂体切除的小鼠通过补充外源性孕酮,就能诱发排卵,若给予抗P血清,则排卵被抑制,且通过补充P又可恢复排卵,然而目前孕酮的作用机理还不清楚。另一方面实验提示,在排卵的最终过程有蛋白分解酶参与。1916年schochet报告小鼠、家兔、猪、人等卵巢中存在胶原酶活性,且其活性随排卵期而变化。由于胶原酶抑制剂能抑制排卵,故人们认为胶原酶与排卵有关系。1957年Albrechtsen报告卵巢中存在血纤维蛋白溶酶原激活因子(PA),后来发现在牛的卵泡液,卵泡壁,小鼠卵巢颗粒细胞中都有PA活性。体外实验已发现PA在小鼠颗粒细胞中的合成和分泌被FSH、LH、cAMP、PGE_1、PGE_2所
Progesterone (P) is involved in a series of processes of follicular rupture. Experiments suggest that P can increase the follicular wall extensibility. Pituitary excised mice can induce ovulation by supplementing exogenous progesterone. If given anti-P serum, ovulation Inhibition, and by supplementing P can restore ovulation, however, the mechanism of action of progesterone is unclear. On the other hand, experiments suggest that protease enzymes are involved in the final process of ovulation. In 1916 schochet reported collagenase activity in the ovaries of mice, rabbits, pigs, and humans, and its activity varied with ovulation. As collagenase inhibitors can inhibit ovulation, it is believed that collagenase and ovulation have a relationship. In 1957 Albrechtsen reported the presence of plasminogen activator (PA) in the ovary and later found to have PA activity in bovine follicular fluid, follicular wall, and mouse ovarian granulosa cells. In vitro experiments have found PA synthesis and secretion in mouse granulosa cells by FSH, LH, cAMP, PGE_1, PGE_2