论文部分内容阅读
目的分析乙型肝炎后肝硬化失代偿期患者中HBe Ag阴性者与HBe Ag阳性者的血清病毒学指标、肝功能检测结果的差异。方法将90例乙肝后肝硬化失代偿患者分为HBe Ag阴性组和HBe Ag阳性组,观察年龄、性别、乙肝病毒基因型、血清病毒DNA载量、肝功能指标等的差异。结果 HBe Ag阴性组和HBe Ag阳性组比较,年龄、性别、肝功能指标、Child-Pugh分级均无差异;HBe Ag阴性组血清乙肝病毒DNA载量(5.14±0.63)log 10copies/ml低于HBe Ag阳性组(6.66±0.75)log10copies/ml,(t=10.386,P<0.001);两组乙肝病毒基因型的比较差异有统计学意义,HBe Ag阴性组基因型B占26.2%(11/42),基因型C占54.8%(23/42),B/C混合型占19.0%(8/42),HBe Ag阳性组基因型B占12.5%(6/48),基因型C占87.5%(42/48),(χ2=14.580,P<0.001)。结论 HBe Ag阴性与阳性乙型肝炎后肝硬化失代偿期患者在乙肝病毒基因型构成特点、病毒DNA载量上有差异,两组肝功能受损程度没有显著差异。
Objective To analyze the differences of serum virological and liver function tests between HBeAg-negative and HBeAg-positive patients with decompensated hepatitis B after liver cirrhosis. Methods Ninety patients with decompensated hepatitis B after liver cirrhosis were divided into two groups: HBe Ag negative group and HBe Ag positive group. The differences of age, sex, HBV genotype, serum HBV DNA load and liver function were observed. Results There was no difference in age, sex, liver function index and Child-Pugh classification between HBeAg negative group and HBeAg positive group. The DNA load of HBeAg negative group was lower than HBeAg (5.14 ± 0.63) log 10copies / ml (6.66 ± 0.75) log10copies / ml, (t = 10.386, P <0.001). There was significant difference between the two groups in the genotypes of hepatitis B virus, genotype B in HBeAg negative group accounted for 26.2% (11/42 ) Genotype C accounted for 54.8% (23/42), B / C mixed accounted for 19.0% (8/42), HBeAg positive genotype B accounted for 12.5% (6/48), genotype C accounted for 87.5% (42/48), (χ2 = 14.580, P <0.001). Conclusions HBeAg-negative and HBeAg-decomposing patients have different genotypes of HBV genotypes and different viral DNA loads. There is no significant difference in the extent of liver damage between the two groups.