论文部分内容阅读
AIM:To investigate the expression of Survivin in pancreaticcancer and its correlation to the expression of Bcl-2.METHODS:Survivin and Bcl-2 expressions were examinedby immunohistochemistry in 42 tissue samples frompancreatic cancer and 10 from normal pancrease.RESULTS:No survivin expression was detected in the tissuesamples from normal pancrease,while it was detected in34 of 42 tissue samples from pancreatic cancer (81.95%).There was a correlation between survivin expression anddifferentiation and stages of pancreatic cancer.Survivinpositive cases were strongly correlated to Bcl-2 expression(28/30 vs6/12,P<0.05).CONCLUSION:Overexpression of survivin plays animportant role in the development and progression ofpancreatic cancer,and correlates to the expression of Bcl-2.Survivin expression can be used as a prognostic factor.
AIM: To investigate the expression of Survivin in pancreatic cancer and its correlation to the expression of Bcl-2.METHODS: Survivin and Bcl-2 expressions were examined by immunohistochemistry in 42 tissue samples from pancreatic cancer and 10 from normal pancrease .RESULTS: No survivin expression was detected in the tissues samples from normal pancrease, while it was detected in 34 tissue samples from pancreatic cancer (81.95%). There was a correlation between survivin expression and differentiation and stages of pancreatic cancer. Survivinpositive cases were strongly correlated to Bcl-2 expression 28/30 vs 6/12, P <0.05) .CONCLUSION: Overexpression of survivin plays animportant role in the development and progression of pancreatic cancer, and correlates to the expression of Bcl-2.Survivin expression can be used as a prognostic factor.