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背景:MRI对帕金森病(Parkinson’sdisease,PD)的评估是一个有用的非创伤性的检测手段。近来有研究发现PD患者MRI的白质高信号(whitematterhyperintensities,WMH)的发生率高于正常老年人,然而WMH对PD的临床特征的影响还没有被阐明。目的:探讨白质高信号与PD临床特征的关系。设计:采用随机、对照和盲法进行病例对照研究。地点和对象:PD患者均选择在1996-01/2003-06在西京医院神经科门诊就诊及住院患者,60例对照者均选择为年龄匹配的健康自愿者。干预措施:由两位有经验的放射科医师对比分析PD组和对照组中MRI的WMH的发生率和程度,并研究WMH和PD临床特征之间的关系。主要观察指标:PD组和对照组中MRI的WMH包括侧脑室周围白质高信号(periventricularhyperintensities,PVH)和半卵圆中心白质高信号(centrumsemiovalehyperintensities,CSH)的发生率和程度;PD的临床特征犤病程、病情(根据Hoehn-Yahr分级)犦和疾病进展指数(Hoehn-Yahr)分级与病程之间的比值。结果:PD组比对照组PVH的发生率明显增高(40%和22%,χ2=6.125)和程度明显加重犤(.81±0.52)分和(1.23±0.60)分;t=3.333犦,并且有PVH的PD患者比无PVH的PD患者具有更短的病程犤(6.11±2.31)年和(7.81±2.50)年;t=3.278犦、更严重的病情犤Hehn-Yahr分级:(2.68±0.
Background: The assessment of Parkinson’s disease (PD) by MRI is a useful noninvasive means of detection. Recently, studies have found that the incidence of white matter hyperintensities (MRI) in patients with PD is higher than that of normal elderly patients. However, the effect of WMH on the clinical features of PD has not been elucidated. Objective: To investigate the relationship between white matter high signal and clinical features of PD. Design: A case-control study was conducted using randomized, controlled and blinded methods. Location and Subjects: All patients with PD were enrolled in the neurology outpatient department and hospitalized patients in Xijing Hospital from January 1996 to June 2003, and 60 healthy controls were selected as age-matched healthy volunteers. Interventions: Two experienced radiologists compared the incidence and extent of WMH in MRI in the PD and control groups and studied the relationship between the clinical features of WMH and PD. MAIN OUTCOME MEASURES: The WMH of MRI in PD group and control group includes the incidence and extent of periventricular hyperintensities (PVH) and centrum semiovalehyperintensities (CSH) in the PD group and the control group. The clinical features of PD , The disease (according to Hoehn-Yahr classification), and the ratio of disease progression to disease progression index (Hoehn-Yahr). Results: The incidence of PVH in PD group was significantly higher than that in control group (40% vs 22%, χ2 = 6.125) and significantly increased (81 (.81 ± 0.52) points vs (1.23 ± 0.60) points, t = 3.333 犦) PD patients with PVH had a shorter duration of disease (6.11 ± 2.31) years and (7.81 ± 2.50) years compared with those without PVH; t = 3.278 犦, and the more severe ones were Hehn-Yahr classification: (2.68 ± 0 .