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自1988年1月至1996年1月采用CT引导立体定向技术对300例颅咽管瘤进行了385次瘤内置入放射性核素的治疗.其中男180例,女120例,年龄3~74岁,平均30.5岁.全部病例均有视路受损症状.CT或MRI检查显示:囊性肿瘤175例,实体性肿瘤40例,实体与囊腔并存85例.无手术死亡及严重并发症.结果:术后250例随访6个月至8年,平均4年:肿瘤消失180例(72%);肿瘤显著缩小(>80%)30例(12%);肿瘤缩小50%左右20例(8%);肿瘤增大(主要为实体性)16例(6.4%),死亡4例(1.6%).所使用的P-32和Y-90是纯Beta射线源,因其穿透能力短,易于运送与保存、防护.使用囊壁的治疗量为200Gy(20 000 rd)为好,可杀死瘤细胞而对周围组织无损害.表明立体定向瘤内放射性核素行间质内照射是治疗颅咽管瘤的一种有效方法.
From January 1988 to January 1996 CT-guided stereotactic technique was used to treat 385 cases of intratumoral radionuclides in 300 cases of craniopharyngiomas, including 180 males and 120 females, aged 3 to 74 years , An average of 30.5 years old.All patients had visual impairment of the pathology.CT or MRI examination showed: cystic tumor in 175 cases, solid tumors in 40 cases, entity and cyst coexist in 85 cases.No operative mortality and serious complications.Results : 250 cases were followed up for 6 months to 8 years with an average of 4 years: 180 cases (72%) disappeared in the tumor; 30 (12%) tumors were significantly reduced (> 80%); (P <0.05), P-32 and Y-90 were pure Beta-ray sources, and their penetrating ability was short, Easy to transport and preservation, protection The use of cystic wall treatment volume of 200Gy (20 000 rd) is good, can kill the tumor cells without damage to the surrounding tissue .It shows that stereotactic radionuclide interstitial irradiation is the treatment An effective method for craniopharyngioma.