1971年Vane等首先提出,阿斯匹林样物质的作用环节是抑制内源性前列腺素(prostaglandin,PG)的合成.以后发现一些非甾体类的抗炎药物,如消炎痛,布洛芬和灭酸制剂等,都可引起前列腺素合成酶不可逆地失活,而使PG的合成受抑制.近年来,随着对PG的生理与病理作用的深入研究,人们对前列腺素合成酶抑制剂(prostaglandin synthesis inhibitors,PGSI)的临床应用产生了很大兴趣.本文综合有关文献,着重介绍PGSI在妇产 In 1971, Vane et al. First proposed that aspirin-like substances can inhibit the synthesis of endogenous prostaglandin (PG) and later found that some non-steroidal anti-inflammatory drugs such as indomethacin, ibuprofen And molluscic acid preparations, can cause irreversible inactivation of prostaglandin synthase, leaving the synthesis of PG inhibited.In recent years, with the physiological and pathological PG in-depth study, people prostaglandin synthase inhibitor (prostaglandin synthesis inhibitors, PGSI) has great interest in clinical application.This article synthesizes the relevant literature, focusing on PGSI in maternity