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吡喹酮(Praziquantel, Biltricide, Droncit, Embay 8440),化学名2—环己甲酰基—1,2,3,4,6,7,11b—六氢—2H—吡嗪并(2,1—a)异喹啉—4—酮,分子式C_(19)H_(24)N_2O_2;分子量为314.42。是1675年由国外研制的一种新型广谱抗寄生虫药物。最初用于绦虫病的治疗,以后又发现对人体三种血吸虫和其它吸虫也有良好的治疗效果。国内于1977年开始合成此药。由于吡喹酮较其它同类抗寄生虫药物有抗虫谱广,服用方便,所需剂量小,疗程短且治疗效果好,副作用轻等优点,近年来在国内外得到广泛应用。根据手头所看到的资料,本文就吡喹酮的药理作用和临床应用作以综述。
(Praziquantel, Biltricide, Droncit, Embay 8440), chemical name 2-cyclohexanecarboxy-1,2,3,4,6,7,11b-hexahydro-2H-pyrazino (2,1- a) isoquinolin-4-one, molecular formula C_ (19) H_ (24) N_2O_2; molecular weight of 314.42. Is a new broad-spectrum anti-parasitic drug developed by foreign countries in 1675. Initially used for the treatment of taeniasis, and later found on the human body three kinds of schistosomes and other trematodes also have a good therapeutic effect. Domestic synthesis of this medicine in 1977. As praziquantel than other similar anti-parasite drugs have a broad spectrum of anti-insect, easy to take, the required dose is small, short course and good therapeutic effect, side effects of light advantages, in recent years at home and abroad have been widely used. According to the information we see at hand, this article reviews the pharmacological effects and clinical application of praziquantel.