药物作用的个体差异及其分型是临床药理学研究的重要课题。越来越多的事实证明,药物代谢的个体差异是造成药物作用个体差异原因之一。除了环境、年龄、食物、合并用药、病理状态等影响因素外,遗传也是重要的影响因素。人体对药物的乙酰化反应速率可划分为快、慢两型,快慢型乙酰化反应与异烟肼的给药方案及肝脏毒性的关系,早为人们所熟知。晚近,经肝药酶代谢的某些药物氧化反应中,也发现有遗传性的快慢型 Individual differences in the role of drugs and their classification is an important issue in clinical pharmacology. More and more facts have proved that individual differences in drug metabolism are one of the causes of individual differences in drug effects. In addition to environment, age, food, medication, pathological status and other influencing factors, genetics is also an important factor. The human acetylation reaction rate can be divided into fast and slow type, fast and slow acetylation and isoniazid dosing regimens and liver toxicity, as early as people are well known. Recently, the liver enzyme metabolism of certain drugs in the oxidation reaction, but also found that the genetic type of fast