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本文应用ｐＨ敏感的ＢＣＥＣＦ和Ｃａ敏感的Ｆｕｒａα萤光染料，分别测定雄性。１６周龄ＳＨＲＳＰ和ＷＫＹ循环淋巴细胞ｐＨｉ，Ｎａ￣＋－Ｈ￣＋交换活性和［Ｃａ￣（２＋）］ｉ，结果表明ＳＨＲＳＰ循环淋巴细胞ｐＨｉ、Ｎａ￣＋－Ｈ￣＋交换活性和［Ｃａ￣（２＋）］ｉ均显著高于ＷＫＲ，而细胞缓冲能力在两组大鼠之间没有显著差异。提示在ＳＨＲＳＰ细胞膜可能存在Ｎａ￣＋，Ｈ￣＋交换遗传性缺陷。将两组大鼠的资料合并，经直线回归相关分析发现ｐＨｉ与Ｎａ￣＋－Ｈ￣＋交换活性和ｐＨｉ与［Ｃａ（２＋）］ｉ均呈显著正相关。表明Ｎａ￣＋－Ｈ￣＋交换活性和［Ｃａ￣（２＋）］ｉ参与ｐＨｉ调节．它们之间既相互调节又相互制约。细胞内Ｎａ、Ｃａ和细胞膜Ｎａ￣＋－Ｈ￣＋离子转运系统异常可能是高血压病因中重要因素之一。
In this paper, pH-sensitive BCECF and Ca-sensitive Furaα fluorescent dye were used to determine the male. The results showed that the SHRSP and WKY circulating lymphocytes pHi, Na ~ + -H ~ + exchange activity and [Ca ~ (2 +)] i at 16 weeks of age showed that the exchange activity of SHRSP circulating lymphocytes pHi, Na ~ + -H ~ ~ (2 +)] i were significantly higher than WKR, while the cell buffering capacity in the two groups of rats did not differ significantly. Tip SHRSP cell membrane may exist Na ~ +, H ~ + exchange genetic defects. The data of two groups of rats were merged. Correlation analysis showed that pHi was positively correlated with Na ~ + -H ~ + exchange activity and pHi with [Ca (2 +)] i. Indicating that Na ~ + -H ~ + exchange activity and [Ca ~ (2 +)] i are involved in pHi regulation. They regulate each other and restrict each other. Abnormality of intracellular Na, Ca and Na ~ + -H ~ + ion transport system may be one of the important factors in the etiology of hypertension.