人类肿瘤坏死因子(TNF)是来源于单核巨噬细胞的蛋白质。过去认为它的主要作用是杀伤肿瘤细胞,最近的研究结果表明它除了具有抗肿瘤作用外,还具有多种调节细胞分裂的生物学功能,如抑制脂蛋白脂酶,活化多形核白细胞,刺激骨吸收,抑制骨形成,刺激胶原酶和前列腺素E_2产生,刺激成纤维细胞生长等。据报导TNF还可诱导白细胞介素1等炎症介质的产生。这些 Human tumor necrosis factor (TNF) is a protein derived from mononuclear macrophages. In the past that its main role is to kill tumor cells, recent studies have shown that it has antitumor effects, but also has a variety of biological functions that regulate cell division, such as inhibition of lipoprotein lipase, activation of polymorphonuclear leukocytes, stimulation Bone resorption, inhibiting bone formation, stimulating collagenase and prostaglandin E_2 production, stimulating fibroblast growth and the like. TNF has also been reported to induce interleukin-1 and other inflammatory mediators. These ones