最近Costa等和Colpaest等提出福氏佐剂引起的大鼠关节炎可以作为临床疼痛研究的一个动物模型。Costa等根椐临床表现和活动情况,将大鼠佐剂关节炎的病程分为四期,即临床前期(注射福氏佐剂后10天左右),急性期(第15—30天),急性后期(第30—50天)和晚期(第50—60天)。另有报告指出,佐剂关节炎大鼠的神经组织,特别是脊髓内的P—物质在急性期有明显的增加,认为与关节痛有关。本实验进一 Recently, Costa et al. And Colpaest et al. Proposed that Freund’s adjuvant-induced arthritis in rats may serve as an animal model for clinical pain research. Costa and other root 椐 clinical manifestations and activities, the course of the rat adjuvant arthritis is divided into four phases, namely, preclinical (injection of Freund’s adjuvant about 10 days), acute (15-30 days), acute Late (day 30-50) and late (day 50-60). Another report pointed out that adjuvant arthritis in rats, nerve tissue, especially in the spinal cord P-substance in the acute phase had a significant increase, that with the joint pain. This experiment into one