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目的：测定鬼臼酰肼哌啶腙氮氧自由基（ＧＰ＿１）小鼠单次静注半衰期。方法：用ＥＳＲ仪测定血样品中ＧＰ＿１的浓度，对实验结果进行分析。结果：鬼臼酰肼哌啶腙氮氧自由基（ＧＰ＿１）的浓度在１０μｇ／ｍｌ至１ｍｇ／ｍｌ间的血样品中，顺磁共振讯号强度曲线的主峰高度与小鼠血中该药浓度为一线性关系，ＧＰ＿１小鼠单次静脉注射，小鼠血中该药浓度与时间的曲线可用Ｃ＝２８３１．４（μｇ／ｍｌ）ｅ￣（－０．２６７ｔ）＋６２５．２（μｇ／ｍｌ）ｅ￣（－０．０３４６ｔ）公式表示；小鼠血中该药浓度消除相半衰期为２０．０３分。结论：ＧＰ＿１小鼠单次静注数学模型更适合于２或３房室模型。
AIM: To determine the single intravenous half-life of podophylloperazide piperidine hydrazone nitroxide (GP_1) mice. Methods: The concentration of GP_1 in blood samples was determined by ESR and the experimental results were analyzed. Results: The peak height of the paramagnetic resonance signal intensity curve in the blood sample of 10μg / ml to 1mg / ml of pheophyllide hydrazone piperidine hydrazone nitroxide (GP_1) concentration was A linear relationship, a single intravenous injection of GP_1 mice, blood concentration of the drug and the time curve C = 2831.4 (μg / ml) e ~ (-0.267t) +625.2 (μg / ml) e ~ (-0.0346t) formula; the blood concentration of the drug in mice elimination phase half-life of 20.03 points. Conclusion: The single-injection mathematical model of GP_1 mice is more suitable for 2 or 3-compartment model.