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为阐明脑胶质瘤瘤周CT低密度区（CT－PTLDA）本质及其与预后的关系，本研究对20例胶质瘤瘤周CT低密度区的宽度进行分级，并以光镜观察其病理特征；结合CT平扫及增强扫描的影像，取代表性的14例肿瘤瘤体、水肿区和正常脑组织进行电镜观察比较。结果显示：（1）CT－PTLDA内可见瘤细胞浸润；（2）电镜下可见瘤体及瘤周毛细血管内皮细胞呈不同程度肿胀，紧密连接扩张、扭曲，基膜完整但厚薄不均，胶质膜局部缺损。CT－PTLDA越宽其血脑屏障改变也越严重；（3）CT－PTLDA宽度与预后密切相关，CT－PTLDA越宽预后越差。以上结果提示脑胶质瘤CT－PTLDA是瘤细胞浸润扩散的实际范围及伴有脑水肿的表现，对CT－PTLDA宽度进行分级有助于对预后的判断。笔者建议在胶质瘤手术中应尽可能切除非功能区组织的水肿带，以免留下肿瘤复发根源。
In order to elucidate the nature of CT-PTLDA in gliomas and its relationship with prognosis, we studied the CT-PTL widths of 20 patients with gliomas in this study and observed by light microscopy Pathological features; combined with CT scan and enhanced imaging, instead of the representative of 14 cases of tumor, edema area and normal brain tissue under electron microscope comparison. The results showed that: (1) Infiltration of tumor cells was observed in CT-PTLDA; (2) Tumor cells and peritumoral capillary endothelial cells showed swelling in varying degrees under electron microscope, closely connected with expansion, distortions, Plasma membrane partial defect. CT-PTLDA wider blood-brain barrier changes are more serious; (3) CT-PTLDA width and prognosis are closely related to the wider CT-PTLDA prognosis worse. The above results suggest that glioma CT-PTLDA is the actual range of tumor cell infiltration and diffusion accompanied by cerebral edema. To classify the width of CT-PTLDA is helpful to judge the prognosis. I suggest that in glioma surgery should be removed as much as possible edema zone of non-functional zone tissue, so as to avoid leaving the root causes of tumor recurrence.